☆ Walkthrough in Progress: Bookmark for Updates!
★ Best Crest Builds | All Crest Locations
☆ Full Interactive Map of Pharloom!
★ Mask Shards | Spool Fragments | Abilities
☆ Boss Guides: Moorwing | Savage Beastfly | Widow
★ Tasks & Wishes: Berry Picking | The Lost Fleas

Plasmium Phial is a Red tool that you can equip to your crest in Hollow Knight: Silksong. Check out how to get Plasmium Phial, its location, how to refill it, and its effects here!
List of Contents
| Map Location | Overworld |
|---|---|
![]() |
![]() |
Plasmium Phial can be obtained by completing the Alchemist’s Assistant side quest, which you can start by speaking to the Alchemist Assistant in the Wormways.
This quest requires you to locate three Plasmium Plants, all of which can be found without leaving the Wormways.

Once you have used up all your Plasmium Phial charges, you can return at the Wormways and talk to Alchemist Zylotol to refill the tool for 20 Rosaries.
Plasmium Phial grants bonus health points when used. It has limited charges, and once depleted, you’ll need to refill it to keep gaining temporary health.
Be sure to equip this tool to increase your survivability against difficult enemies or bosses.

Equipping the tool while the Architect Crest is active also allows you to overdose on Plasmium. When overdosed, you’ll gain health regeneration indefinitely.
Architect Crest Location and Best Build
Plasmium Phial
|
||
| Slot Color | Uses | Refill Cost |
|---|---|---|
| Red | 5 | 20 |
| Effect | ||
| Spear-phial containing Plasmium. Injecting the liquid allows one to gain health beyond their natural limits. | ||

| Silksong Tools Guides | |
|---|---|
| Best Tools for Each Type | Best Silkshot to Get |
if you use an amount more than your max masks they will turn blue, giving you the ability to regenerate which can not be interrupted even if you get hit, so if you have 5 max health, you will have to use 6 plasmium vials to gain the affect, the affect is lost on death or resting at a bench.
How to Get Plasmium Phial and Effects

Genshin Impact Walkthrough & Guides Wiki

Hollow Knight: Silksong Walkthrough & Guides Wiki

Umamusume: Pretty Derby Walkthrough & Guides Wiki

Borderlands 4 Walkthrough & Guides Wiki
Wuthering Waves Walkthrough & Guides Wiki
Honkai: Star Rail Walkthrough & Guides Wiki
Pokemon TCG Pocket (PTCGP) Strategies & Guides Wiki

Pokemon Scarlet and Violet (SV) Walkthrough & Guides Wiki
Zenless Zone Zero Walkthrough & Guides Wiki

Clair Obscur: Expedition 33 Walkthrough & Guides Wiki
Fire Emblem Heroes (FEH) Walkthrough & Guides Wiki
Yu-Gi-Oh! Master Duel Walkthrough & Guides Wiki

Persona 3 Reload Walkthrough & Guides Wiki
Once Human Walkthrough & Guides Wiki
Black Myth: Wukong Walkthrough & Guides Wiki
The Legend of Zelda: Tears of the Kingdom Walkthrough & Guides Wiki
Super Smash Bros. Ultimate Walkthrough & Guides Wiki

Monster Hunter World Walkthrough & Guides Wiki

Diablo 4: Vessel of Hatred Walkthrough & Guides Wiki

Elden Ring Shadow of the Erdtree Walkthrough & Guides Wiki
© 2025 Team Cherry
The copyrights of videos of games used in our content and other intellectual property rights belong to the provider of the game.
The contents we provide on this site were created personally by members of the Game8 editorial department.
We refuse the right to reuse or repost content taken without our permission such as data or images to other sites.
Can I still get this in act 3